Aplysia Medical AB
© Aplysia Medical AB  2019
Computed tomography reconstruction of persistent duct in a 76 years old woman.


Selected scientifical publications

Peer-reviewed articles

1. Falk L, Sallisalmi M, Lindholm J, Lindfors M, Frenckner B, Broome M, Broman M. Differential hypoxemia during venoarterial extracorporeal membrane oxygenation. Perfusion. 2019;34(EuroELSO 2019):22-9. 2. Maksuti E, Westerhof B, Ugander M, Donker D, Carlsson M, Broome M. Cardiac Remodeling in Aortic and Mitral Valve Disease  – a Simulation Study with Clinical Validation. J Appl Phys. 2019;In press. 3. Donker DW, Brodie D, Henriques JPS, Broome M. Left Ventricular Unloading during Veno- Arterial ECMO - A Simulation Study. ASAIO J. 2018;65(1):11-20. 4. Donker DW, Brodie D, Henriques JPS, Broome M. Left ventricular unloading during veno- arterial ECMO: a review of percutaneous and surgical unloading interventions. Perfusion. 2018;34(2):98-105. 5. Donker DW, Meuwese CL, Braithwaite SA, Broome M, van der Heijden JJ, Hermens JA, Platenkamp M, de Jong M, Janssen JGD, Balik M, Belohlavek J. Echocardiography in extracorporeal life support: A key player in procedural guidance, tailoring and monitoring. Perfusion. 2018;33(1_suppl):31-41. 6. Frenckner B, Broman M, Broome M. Position of draining venous cannula in extracorporeal membrane oxygenation for respiratory and respiratory/circulatory support in adult patients. Crit Care. 2018;22(1):163. 7. Brodie D, Curtis JR, Vincent JL, Bakker J, Brown CE, Creteur J, Papazian L, Sladen RN, Ranieri VM, participants in the Round Table C. Treatment limitations in the era of ECMO. Lancet Respir Med. 2017. 8. Maksuti E, Carlsson M, Arheden H, Kovacs SJ, Broome M, Ugander M. Hydraulic forces contribute to left ventricular diastolic filling. Sci Rep. 2017;7:43505. 9. Broome M. Scarce resources call for us to weigh the pros and cons of every single decision. Acta Paediatr. 2016;105(8):880. 10. Broome M, Donker DW. Individualized real-time clinical decision support to monitor cardiac loading during venoarterial ECMO. J Transl Med. 2016;14(1):4. 11. Lindfors M, Frenckner B, Sartipy U, Bjallmark A, Broome M. Venous Cannula Positioning in Arterial Deoxygenation During Veno-Arterial Extracorporeal Membrane Oxygenation-A Simulation Study and Case Report. Artif Organs. 2016. 12. Maksuti E, Westerhof N, Westerhof BE, Broome M, Stergiopulos N. Contribution of the Arterial System and the Heart to Blood Pressure during Normal Aging - A Simulation Study. PLoS One. 2016;11(6):e0157493. 13. Broman M, Frenckner B, Bjallmark A, Broome M. Recirculation during veno-venous extra- corporeal membrane oxygenation - a simulation study. The International journal of artificial organs. 2015;38(1):23-30. 14. Flam B, Broome M, Frenckner B, Branstrom R, Bell M. Authors' Response. J Intensive Care Med. 2015. 15. Flam B, Broome M, Frenckner B, Branstrom R, Bell M. Pheochromocytoma-Induced Inverted Takotsubo-Like Cardiomyopathy Leading to Cardiogenic Shock Successfully Treated With Extracorporeal Membrane Oxygenation. J Intensive Care Med. 2014. 16. Larsson M, Rayzman V, Nolte MW, Nickel KF, Bjorkqvist J, Jamsa A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broome M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renne T. A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk. Science Transl Med. 2014;6(222):222ra17. 17. Maksuti E, Bjallmark A, Broome M. Modelling the heart with the atrioventricular plane as a piston unit. Med Eng Phys. 2014. 18. Broome M, Maksuti E, Bjallmark A, Frenckner B, Janerot-Sjoberg B. Closed-loop real-time simulation model of hemodynamics and oxygen transport in the cardiovascular system. Biomed Eng Online. 2013;12:69. 19. Holzgraefe B, Broome M, Frenckner B, Kalzen H, Palmer K. Comment on Grasso et al.: ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure. Intensive Care Med. 2012. 20. Holzgraefe B, Broome M, Kalzen H, Konrad D, Palmer K, Frenckner B. Extracorporeal membrane oxygenation for pandemic H1N1 2009 respiratory failure. Minerva Anestesiol. 2010;76(12):1043-51. 21. Larsson M, Talving P, Palmer K, Frenckner B, Riddez L, Broome M. Experimental extracorporeal membrane oxygenation reduces central venous pressure: an adjunct to control of venous hemorrhage? Perfusion. 2010;25(4):217-23. 22. Broome M. Reply, Paracorporeal artificial lung circuit as a possibility for bridge to lung transplantation. Ann Thorac Surg. 2009;88(1):352-3. 23. Broome M, Palmer K, Schersten H, Frenckner B, Nilsson F. Prolonged extracorporeal membrane oxygenation and circulatory support as bridge to lung transplant. Ann Thorac Surg. 2008;86(4):1357-60. 24. Frenckner B, Broome M, Lindstrom M, Radell P. Platelet-derived growth factor inhibition--a new treatment of pulmonary hypertension in congenital diaphragmatic hernia? J Pediatr Surg. 2008;43(10):1928-31. 25. Broome M, Haney M, Haggmark S, Johansson G, Aneman A, Biber B. Pressure-independent cardiac effects of angiotensin II in pigs. Acta Physiol Scand. 2004;182(2):111-9. 26. Osterlund B, Jern C, Seeman-Lodding H, Johansson G, Haggmark S, Broome M, Biber B. Intracoronary beta2 receptor activation induces dynamic local t-PA release in the pig. Thromb Haemost. 2003;90(5):796-802. 27. Broome M, Aneman A, Lehtipalo S, Arnerlov C, Johansson G, Winso O, Biber B. Splanchnic vasoconstriction by angiotensin II is arterial pressure dependent. Acta Anaesthesiol Scand. 2002;46(1):57-63. 28. Broome M, Haney M, Osterlund B, Haggmark S, Johansson G, Biber B. The cardiac effects of intracoronary angiotensin II infusion. Anesth Analg. 2002;94(4):787-93, table of contents. 29. Broome M, Haney M, Haggmark S, Johansson G, Aneman A, Biber B. Acute effects of angiotensin II on myocardial performance. Acta Anaesthesiol Scand. 2001;45(9):1147-54. 30. Aneman A, Svensson M, Broome M, Biber B, Petterson A, Fandriks L. Specific angiotensin II receptor blockage improves intestinal perfusion during graded hypovolemia in pigs. Crit Care Med. 2000;28(3):818-23. 31. Broome M, Aneman A, Haney M, Haggmark S, Johansson G, Biber B. Angiotensin II mesenteric and renal vasoregulation: dissimilar modulatory effects with nitroprusside. Acta Anaesthesiol Scand. 2000;44(10):1238-45. 32. Sundeman H, Aneman A, Broome M, Haney M, Johansson G, Haggmark S, Biber B, Winso O. Effects of desflurane on the pig intestinal circulation during hypotension. Acta Anaesthesiol Scand. 1999;43(10):1069-77. 33. Sundeman H, Haney M, Broome M, Haggmark S, Johansson G, Winso O, Biber B. The effects of desflurane on cardiac function as measured by conductance volumetry in swine. Anesth Analg. 1998;87(3):522-8. 34. Broome M, Hokfelt T, Terenius L. Peptide YY (PYY)-immunoreactive neurons in the lower brain stem and spinal cord of rat. Acta Physiol Scand. 1985;125(2):349-52.

Selected abstracts

1. Kuruvilla J, Harikrishnan KN, Broomé M, Vettukattil J. Prediction of Hemodynamics following Atrial Fenestration for Right Ventricular Decompression in Pulmonary Arterial Hypertension: A Simulation Study.  Pulmonary Hypertension Association conference 2016; June 17-19, 2016; Dallas, Texas, USA2016. 2. Samuel B, Kurup H, Broome M, Vettukattil J. Device sizing for atrial flow regulation in HFpEF: A computer simulation model.  CSI - Catheter Interventions in Congenital, Structural and Valvular Heart Disease; June 22-25, 2016; Frankfurt2016. 3. Maksuti E, Broome M. Simulation of Right Ventricular Failure in Patients with Left Ventricular Assist Device.  37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Submission number; Milano: IEEE Engineering in Medicine and Biology Society; 2015. 4. Maksuti E, Carlsson M, Arheden H, Ugander M, Broome M. Lumped-Parameter Modeling of Cardiac Longitudinal Function.  37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Submission number; Milano: IEEE Engineering in Medicine and Biology Society; 2015. 5. Maksuti E, Westerhof N, Westerhof B, Broome M, Stergiopulos N. Cardiac and Arterial Contribution to Blood Pressure Changes with Age.  Artery 15; Krakow2015. 6. Maksuti E, Carlsson M, Arheden H, Broome M, Ugander M. Hydraulic forces contribute to left ventricular diastolic filling 18th Annual SCMR Scientific Sessions 4-7 February Nice, France: JCMR; 2015. p. 79. 7. Broome M, Maksuti E, Frenckner B. Left Ventricular Unloading during Venoarterial Circulatory Assist Therapy – a simulation study.  EuroELSO 2014; May 22-24 2014; Paris2014. 8. Broome M, Frenckner B. Recirculation during veno-venous Extra-Corporeal Membrane Oxygenation - A Simulation Study.  EuroELSO 2013; May 9-11 2013; Stockholm2013. 9. Lindfors M, Lindholm J, Broome M. Arterial deoxygenation during veno-arterial extracorporeal membrane oxygenation - a case report and simulation study.  EuroELSO 2012; Rome2012. 10. Broome M. Hemodynamic determinants of shunt flow in ASD.  XXXVII Nordic Meeting in Pediatric Cardiology; Stockholm2007. 11. Broome M. The Effects of Mitral Regurgitation on Venous Pulmonary Flow and Mitral Flow Svensk Thoraxkirurgisk Förenings Årsmöte; Umeå2004. 12. Maksuti E, Carlsson M, Arheden H, Broomé M, Ugander M, editors. Hydraulic forces contribute to left ventricular diastolic filling. Journal of Cardiovascular Magnetic Resonance; 2015. 13. Maksuti E, Westerhof N, Westerhof B, Broome M, Stergiopulos N, editors. Cardiac and arterial contribution to blood pressure changes with age. Artery Research; 2015. 14. Broomé M, Maksuti E, Waldenström A, Bjällmark A, editors. Simulation of arterial hypertension and progressive arteriosclerosis with a 0-D multipurpose cardiovascular model. 3rd International Conference on Computational & Mathematical Biomedical Engineering; 2013; Hongkong. Hongkong2013. 15. Maksuti E, Johnson J, Bjällmark A, Broomé M, editors. Physical Modeling of the Heart with the Atrioventricular Plane as a Piston Unit. 3rd International Conference on Computational & Mathematical Biomedical Engineering; 2013; Hongkong. Hongkong2013.

Other relevant scientifical publications.

1. Sun, Y., et al., A comprehensive model for right-left heart interaction under the influence of pericardium and baroreflex. Am J Physiol, 1997. 272(3 Pt 2): p. H1499-H1515. 2. Sun, Y., et al., Mathematical model that characterizes transmitral and pulmonary venous flow velocity patterns. Am J Physiol, 1995. 268(1 Pt 2): p. H476-H489. 3. Mynard, J.P., et al., A simple versatile model of valve dynamics for use in lumped parameter and one-dimensional cardiovascular models. International Journal for Numerical Methods in Biomedical Engineering, 2011. 28(6-7): p. 626-641. 4. Arts, T., et al., Adaptation to mechanical load determines shape and properties of heart and circulation: the CircAdapt model. American Journal of Physiology Heart and Circulatory Physiology, 2005. 288(4): p. H1943-H1954. 5. Arts, T., et al., Simulation of adaptation of blood vessel geometry to flow and pressure: Implications for arterio-venous impedance. Mechanics Research Communications, 2012. 42(0): p. 15-21.

The heart is art


Many of the illustrations in Aplysia CardioVascular Lab is produced by the Swedish artist Ebba Åkerman.